Supplementary Table 3.

Inclusion and exclusion criteria according to the population, intervention, comparison/comparator, outcomes, study type model20

	Inclusion criteria	Exclusion criteria
Population	Patients with TT levels T <12 nmol l−1	Eugonadal patients, women
Intervention	TRT	Other treatments (e.g., SERMs, AIs) alone or in combination with testosterone
Comparison	Placebo or no therapy	Other treatments (e.g., SERMs, AIs)
Outcomes	Arterial thrombotic events (all districts, stroke, myocardial infarction, upper limbs, lower limbs) VTE (all districts, DVT, portal vein thrombosis, splenic thrombosis, pulmonary embolism) Mortality	/
Study type	Observational studies, randomized controlled studies, case-control studies	Animal studies, in vitro studies, review and meta-analyses, case reports, book chapters, editorials

AIs: aromatase inhibitors; DVT: deep vein thrombosis; SERMs: selective estrogen receptor modulators; VTE: venous thromboembolism; TRT: testosterone replacement therapy; TT: total testosterone