Table 1.
Obtained topics from the LDA.
| Name | Top 10 words | Slope | P value | Type | |
|---|---|---|---|---|---|
| Topic 1 | The Impact of Research and Development Programs on Community Health | research, develop, program, health, investig, project, collabor, communiti, support, science | −0.159 | .000 | Cold topic |
| Topic 2 | Ethical Considerations in Clinical Trials | ethic, trial, approv, dissemin, committe, randomis, analysi, outcom, peer review, include | 0.089 | .000 | Hot topic |
| Topic 3 | Comparing Oocyte Therapies for Different Disease Cycles | oocyt, therapi, respons, compar, differ, number, diseas, cycl, system, phase | −0.005 | .762 | |
| Topic 4 | Enrollment and Data Reporting in Clinical Trials | clinic, trial, enrol, data, report, particip, random, compar, investig, includ | 0.014 | .411 | |
| Topic 5 | Comparing the Effects of Pregnancy and Birth on Women and Men | women, pregnanc, differ, birth, men, compar, contrast, effect, random, outcom | 0.004 | .838 | |
| Topic 6 | Medical Data Collection and Analysis Methods | data, research, inform, investig, system, clinic, provid, method, databas, includ | −0.093 | .000 | Cold topic |
| Topic 7 | Investigating HIV Load and ART Participation Over Time | HIV, load, art, particip, time, oral, test, health, viral, investig | −0.058 | .001 | Cold topic |
| Topic 8 | Improving Atopic Dermatitis Treatment | improv, atop, subject, assess, dermat, easi, skin, investig, signific, achiev | 0.015 | .391 | |
| Topic 9 | Randomized Trials on Blood Pressure and Hypertension | random, pressur, blood, hypertens, trial, ablat, outcom, effect, compar, cathet | −0.030 | .083 | |
| Topic 10 | Exploring Stroke Outcomes | Stroke, outcom, trial, random, ischem, scale, clinic, onset, time, therapi | 0.049 | .005 | Hot topic |
| Topic 11 | Animal Models and Clinical Research Methods | system, data, investig, time, anim, standard, model, laser, research, safeti | −0.068 | .000 | Cold topic |
| Topic 12 | Clinical Trial Registry and Randomized Controlled Trials | trial, RCTs, registri, clinic, investig, exercis, data, includ, effect, random | −0.002 | .920 | |
| Topic 13 | Survival and Therapeutic Response in Cancer Trials | surviv, cancer, respons, trial, chemotherapi, phase, overal, therapi, combin, grade | 0.121 | .000 | Hot topic |
| Topic 14 | Studies and Predictive Analyses of Fractures and Osteoporosis | Fractur, model, system, investig, delay, age, predict, respons, effect, bone | −0.015 | .387 | |
| Topic 15 | HCV Genotypes and Sustained Virological Response Rates | HCV, hepat, trial, genotyp, SVR, respons, effect, data, signific, investig | −0.021 | .220 | |
| Topic 16 | Comparative Nutritional Studies | Nutrit, risk, compar, outcom, associ, mortal, clinic, hospit, signific, adjust | 0.074 | .000 | Hot topic |
| Topic 17 | Early Arthritis Treatment With Methotrexate | diseas, arthriti, joint, activ, methotrex, score, clinic, MTX, earli, therapi | 0.028 | .112 | |
| Topic 18 | Insulin Effects in Type 2 Diabetes | insulin, diabet, type, glucos, signific, effect, chang, weight, HbAc, compar | −0.003 | .858 | |
| Topic 19 | Investigating Brain Development and Mechanisms of Disease | diseas, investig, brain, develop, research, sever, gene, factor, system, mechan | −0.202 | .000 | Cold topic |
| Topic 20 | Improving Healthcare Interventions Through Nursing Research, Informatics, and Education | care, health, intervent, particip, nurs, research, inform, interview, educ, practic | −0.084 | .000 | Cold topic |
| Topic 21 | Antibiotic Therapy Trials in COPD and Sepsis | trial, antibiot, clinic, random, therapi, outcom, sepsi, CPAP, infect, COPD | 0.033 | .057 | |
| Topic 22 | COVID-19 Trials and Randomized Outcomes | trial, outcom, includ, covid, randomis, risk, effect, data, particip, review | 0.027 | .121 | |
| Topic 23 | Stem Cell Therapies in Cancer Treatment | cell, tumor, cancer, clinic, stem, therapi, trial, immun, combin, respons | −0.019 | .263 | |
| Topic 24 | Pain and Symptom Improvement Scores | score, improv, pain, symptom, effect, scale, signific, assess, chang, trial | 0.037 | .031 | Hot topic |
| Topic 25 | Research Grants and Funding Programs | Research, grant, fund, institut, program, applic, health, NIH, investig, nation | −0.059 | .001 | Cold topic |
| Topic 26 | Analysis of Drug-Gene Interactions and Their Effects | drug, gene, effect, express, data, ABUS, evalu, chang, test, includ | −0.029 | .098 | |
| Topic 27 | Site Protocol and Process in Clinical Research | research, protocol, site, process, investig, clinic, review, particip, institut, data | −0.002 | .891 | |
| Topic 28 | Studies of the Effect of Placebo in Clinical Trials | placebo, event, advers, receiv, dose, safeti, assign, plus, random, efficaci | 0.099 | .000 | Hot topic |
| Topic 29 | Cancer Drug Development | trial, clinic, drug, research, conduct, investig, develop, investigator-initi, phase, cancer | −0.056 | .001 | Cold topic |
| Topic 30 | Effect of Cognitive Therapy on Pediatric Disorders | therapi, trial, disord, effect, schizophrenia, pediatr, cognit, includ, clinic, investig | −0.019 | .269 | |
| Topic 31 | Preventive Intervention and Risk Assessment for Depression | includ, risk, depress, therapi, intervent, prevent, review, assess, light, compar | −0.009 | .624 | |
| Topic 32 | Quality Assessment and Effectiveness Trials in Psoriasis | qualiti, assess, effect, trial, psoriasi, therapi, evid, includ, outcom, particip | 0.009 | .599 | |
| Topic 33 | Ventilatory Care and Oxygen Therapy in ICU | ventil, care, ICU, oxygen, ill, critic, mechan, outcom, respiratori, intens | 0.016 | .354 | |
| Topic 34 | Research Equipment, Clinical Funding and Scientific Research Development Support | research, devic, clinic, fund, nation, institut, investig, support, translat, lung | −0.029 | .099 | |
| Topic 35 | Comparing the Effects of Inhibitors and Baseline Measurements on Statin Therapy | effect, trial, inhibitor, chang, random, baselin, clinic, compar, statin, measur | 0.030 | .086 | |
| Topic 36 | Vision Improvements Following Implant and ICD in Wound and Acuity Cases | implant, ICD, eye, visual, wound, acuiti, receiv, effect, clinic, trial | 0.002 | .914 | |
| Topic 37 | Exploring Gene Identification Data to Enhance Treatment Strategies for Infants | clinic, diseas, therapi, trial, data, investig, testosteron, infant, advanc, increas | −0.035 | .042 | Cold topic |
| Topic 38 | Randomized Valve Trials and Balloon Angioplasty | trial, primari, random, valv, clinic, balloon, outcom, stenosi, patenc, compar | 0.079 | .000 | Hot topic |
| Topic 39 | Randomized Trials on Coronary Artery Disease | trial, random, coronari, primari, bleed, risk, event, outcom, myocardi, stroke | 0.074 | .000 | Hot topic |
| Topic 40 | Cardiac Arrest and Randomized Trials | trial, cardiac, outcom, arrest, random, primari, includ, clinic, mortal, improv | 0.024 | .171 | |
| Topic 41 | Cancer Survival Rates and Responsiveness to Sorafenib | cancer, surviv, respons, diseas, carcinoma, breast, sorafenib, progress, mutat, overall | 0.057 | .001 | Hot topic |
| Topic 42 | Comparing Postoperative Surgical Outcomes in Kidney Transplants | surgeri, postop, kidney, trial, transplant, random, complic, function, compar, outcom | 0.049 | .005 | Hot topic |
| Topic 43 | Randomized Trials on Coronary Stents | stent, trial, coronari, lesion, clinic, myocardi, infarct, random, failur, cardiac | 0.077 | .000 | Hot topic |
| Topic 44 | Comparing Randomized Trials on Blood Transfusions | trial, clinic, random, bleed, transfus, primari, outcom, blood, vitamin, compar | 0.048 | .006 | Hot topic |
| Topic 45 | Vaccine Safety Investigations | vaccin, advers, safeti, event, seizur, includ, report, investig, dose, random | −0.003 | .842 |
The documentation for 2023 was excluded from the study of temporal trends due to incomplete publications for that year.
ART = antiretroviral therapy, COPD = chronic obstructive lung disease, COVID-19 = corona virus disease 2019, HCV = hepatitis C virus, HIV = human immunodeficiency virus, ICD = implantable cardioverter defibrillator, ICU = intensive care unit, LDA = latent Dirichlet allocation, NIH = National Institutes of Health.