TABLE 4.
Association Between Best-Corrected Visual Acuity and Ellipsoid Zone Integrity.
| Baseline BCVA, letters | Baseline Ellipsoid Zone Status |
|||
|---|---|---|---|---|
| Normal (1) | Questionably Abnormal (2) | Definitely Abnormal (Patchy) (3) | Definitely Abnormal (Absent) (4) | |
| (n = 59) | (n = 40) | (n = 29) | (n = 16) | |
| Mean (SE)a | 64.6 (2.11) | 59.1 (2.23) | 52.4 (2.60) | 38.4 (3.58) |
| Difference (95% CI) vs 1b | — | 3.2 (−4.8, 11.2) | 7.5 (−1.8, 16.9) | 20.1 (8.2. 32.0) |
| P value vs 1 | — | .721 | 0.159 | <.001 |
| Difference (95% CI) vs 2 | — | — | 4.3 (−5.1, 13.7) | 16.9 (5.2, 28.6) |
| P value vs 2 | — | — | .633 | .001 |
| Difference (95% CI) vs 3 | — | — | — | 12.6 (0.7, 24.5) |
| P value vs 3 | — | — | — | .034 |
| Baseline Ellipsoid Zone |
||||
| Change from Baseline in BCVA at Week 24 | Normal | Not Normal | ||
|
| ||||
| (n = 53) | (n = 83) | |||
| Mean (SE)a | 11.9 (1.95) | 9.4 (1.46) | ||
| Difference (95% CI)c | — | 6.6 (1.9, 11.3) | ||
| P value | — | .006 | ||
| Change From Baseline in Ellipsoid Zone at Week 24 |
||||
| Change from Baseline in BCVA at Week 24 | Any Improvement | No Improvement or Worsening | ||
|
| ||||
| (n = 55) | (n = 78) | |||
| Mean (SE) a | 12.3 (1.87) | 9.4 (1.53) | ||
| Difference (95% CI)d | — | 1.4 (−2.9, 5.8) | ||
| P value | — | .512 | ||
BCVA = best-corrected visual acuity; CI = confidence interval; CST = central subfield retinal thickness; SE = standard error of the mean.
Note: Spectral-domain optical coherence tomography images with reading center grades of “cannot grade” are excluded from the analysis.
Values represent the sample mean and sample standard error within each group.
Between-group differences and 95% CIs are based on the least square means derived from an analysis of covariance model with baseline BCVA as the dependent variable and the baseline ellipsoid zone grade as the independent variable and baseline CST and age as covariates. P values are adjusted using the Tukey-Kramer method for multiple comparisons.
Between-group differences and 95% CIs are based on the least square means derived from an analysis of covariance model with change from baseline in BCVA at week 24 as the dependent variable, the baseline ellipsoid zone grade as the independent variable, and baseline BCVA, baseline CST, and age as covariates.
Between-group differences and 95% CIs are based on the least square means derived from an analysis of covariance model with change from baseline in BCVA at week 24 as the dependent variable, the change from baseline in ellipsoid zone as the independent variable, and baseline BCVA, baseline CST, and age as covariates.