Table 2.
Correlations Between TLR mRNAs and Other Immunological Markers
| nfkb2 | nfkb1 | CRP | C5AR | CR1 | ITGAM | CR3 | C3b | C4 | IL1B | IL6 | IFNy | NL ratio | Cortisol | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HC | ||||||||||||||
| TLR1 | ||||||||||||||
| Pearson R | .17 | −.09 | .05 | .18 | .389** | .02 | .04 | .279* | .22 | .258* | −.07 | −.02 | .485* | −.19 |
| P-value | .14 | .44 | .70 | .13 | .00 | .86 | .75 | .04 | .10 | .02 | .54 | .87 | .02 | .11 |
| n | 74 | 74 | 65 | 75 | 77 | 77 | 56 | 57 | 57 | 77 | 77 | 77 | 24 | 74 |
| TLR3 | ||||||||||||||
| Pearson R | −.06 | −.18 | −.18 | −.15 | −.05 | −.17 | −.02 | −.13 | −.05 | −.13 | .13 | −.594** | −.21 | −.15 |
| P-value | .62 | .13 | .15 | .19 | .69 | .13 | .90 | .33 | .69 | .24 | .27 | .00 | .32 | .20 |
| n | 74 | 74 | 65 | 75 | 77 | 77 | 56 | 57 | 57 | 77 | 77 | 77 | 24 | 74 |
| TLR4 | ||||||||||||||
| Pearson R | .10 | −.01 | .23 | .323** | .564** | .300** | .02 | .14 | .23 | .390** | −.231* | −.13 | .576** | −.19 |
| P-value | .42 | .95 | .06 | .00 | .00 | .01 | .86 | .29 | .08 | .00 | .04 | .27 | .00 | .10 |
| n | 74 | 74 | 65 | 75 | 77 | 77 | 56 | 57 | 57 | 77 | 77 | 77 | 24 | 74 |
| TLR8 | ||||||||||||||
| Pearson R | .14 | −.01 | .07 | .415** | .383** | .379** | .01 | −.04 | .11 | .413** | −.05 | .19 | .435* | −.15 |
| P-value | .23 | .97 | .61 | .00 | .00 | .00 | .96 | .77 | .42 | .00 | .68 | .09 | .03 | .22 |
| n | 74 | 74 | 65 | 75 | 77 | 77 | 56 | 57 | 57 | 77 | 77 | 77 | 24 | 74 |
| SZ | ||||||||||||||
| TLR1 | ||||||||||||||
| Pearson R | .07 | −.18 | .12 | .281* | .470** | .248* | .10 | .15 | .17 | .278** | .14 | .298** | .234* | .07 |
| P-value | .51 | .10 | .32 | .01 | .00 | .02 | .41 | .22 | .16 | .01 | .20 | .01 | .03 | .52 |
| n | 81 | 81 | 75 | 82 | 85 | 86 | 68 | 68 | 68 | 86 | 86 | 86 | 82 | 86 |
| TLR3 | ||||||||||||||
| Pearson R | .11 | −.09 | −.01 | −.357** | −.317** | −.268* | −.23 | −.15 | −.09 | −.17 | .18 | −.500** | −.572** | .00 |
| P-value | .33 | .43 | .94 | .00 | .00 | .01 | .06 | .21 | .47 | .11 | .10 | .00 | .00 | 1.00 |
| n | 81 | 81 | 75 | 82 | 85 | 86 | 68 | 68 | 68 | 86 | 86 | 86 | 82 | 86 |
| TLR4 | ||||||||||||||
| Pearson R | .04 | −.19 | .10 | .481** | .710** | .484** | .19 | .22 | .13 | .386** | .00 | .314** | .509** | .21 |
| P-value | .72 | .08 | .41 | .00 | .00 | .00 | .13 | .07 | .30 | .00 | .98 | .00 | .00 | .05 |
| n | 81 | 81 | 75 | 82 | 85 | 86 | 68 | 68 | 68 | 86 | 86 | 86 | 82 | 86 |
| TLR8 | ||||||||||||||
| Pearson R | −.13 | −.04 | .16 | .230* | .228* | .320** | .05 | .15 | .16 | .235* | .08 | .12 | .309** | .05 |
| P-value | .24 | .75 | .18 | .04 | .04 | .00 | .69 | .22 | .21 | .03 | .46 | .28 | .00 | .63 |
| n | 81 | 81 | 75 | 82 | 85 | 86 | 68 | 68 | 68 | 86 | 86 | 86 | 82 | 86 |
Note: Pearson R correlations between TLR mRNA and immunological factors in healthy controls (HC) and people with schizophrenia (SZ).
NF-κB1/2, kappa-light-chain-enhancer’ of activated B-cells (mRNA, log transformed); CRP, c-reactive protein; C5ar, complement receptor 5 a (mRNA log transformed); CR1, complement receptor type 1 (mRNA, log transformed); ITGAM/C3a, integrin alpha M/complement factor 3 receptor alpha (mRNA log transformed); C3/C3b/C4 Prot., complement component 3/3b/4 protein; IL1 β, interleukin 1 beta; IL6, interleukin 6; IFN-γ, interferon gamma; NLR, neutrophil/lymphocyte ratio, cortisol in nmol/l.
*P < .05 level,
**P < .01 (2-tailed).