Table 1.
Demographic and clinical characteristics of patients with metastatic ACC, stratified by surgical management. Bold indicates p<0.05.
| Total Cohort (n = 976) |
Operative Management (n = 379) |
Non-Operative Management (n = 597) |
p-value | |
|---|---|---|---|---|
| Mean Age, Years (SD) | 55.2 (15.4) | 53.9 (15.5) | 56.0 (15.3) | 0.035 |
| Sex, n (%) | ||||
| Male | 394 (40.4) | 142 (37.5) | 252 (42.2) | 0.141 |
| Female | 582 (59.6) | 237 (62.5) | 345 (57.8) | |
| Race, n (%) | ||||
| White | 820 (84.0) | 322 (85.0) | 498 (83.4) | 0.475 |
| Black | 96 (9.8) | 32 (8.4) | 64 (10.7) | |
| Other | 60 (6.2) | 25 (6.6) | 35 (5.8) | |
| Ethnicity, n (%) | ||||
| Hispanic | 111 (11.4) | 33 (8.7) | 78 (13.1) | 0.037 |
| Non-Hispanic | 865 (88.6) | 346 (91.3) | 519 (86.9) | |
| Insurance status, n (%) | ||||
| Private | 491 (51.4) | 202 (53.3) | 289 (48.4) | 0.421 |
| Public | 419 (43.8) | 155 (40.9) | 264 (44.2) | |
| Uninsured | 46 (4.8) | 29 (7.7) | 29 (4.9) | |
| Charlson-Deyo Score, n (%) | ||||
| 0 | 699 (71.6) | 272 (71.8) | 427 (71.5) | 0.8416 |
| 1 | 193 (19.8) | 76 (20.1) | 117 (19.6) | |
| 2 | 52 (5.3) | 24 (6.3) | 28 (4.7) | |
| ≥3 | 32 (3.3) | 7 (1.8) | 25 (4.2) | |
| Laterality, n (%) | ||||
| Left | 500 (51.2) | 199 (52.5) | 301 (50.4) | 0.001 |
| Right | 401 (41.1) | 167 (44.1) | 234 (39.2) | |
| Bilateral | 12 (1.2) | 2 (0.5) | 10 (1.7) | |
| Unspecified | 63 (6.5) | 11 (2.9) | 52 (8.7) | |
| Median Tumor Size, cm (IQR) | 11.0 (7.7–15.2) | 10.9 (7.5–14.6) | 12 (8–17) | 0.004 |
| Mean Number of Metastatic Sites, (SD) | 1.37 (0.75) | 1.15 (0.67) | 1.52 (0.76) | <0.001 |
| Location of Metastatic Sites | ||||
| Liver, n (%) | 550 (56.3) | 166 (43.8) | 384 (64.3) | <0.001 |
| Lung, n (%) | 568 (58.2) | 200 (52.8) | 368 (61.6) | 0.003 |
| Brain, n (%) | 35 (3.6) | 5 (1.3) | 30 (5.0) | 0.002 |
| Bone, n (%) | 189 (19.4) | 61 (16.1) | 128 (21.4) | 0.037 |
| Medical Therapy, n (%) | ||||
| Radiation | 606 (62.1) | 209 (55.1) | 397 (66.5) | <0.001 |
| Chemotherapy | 677 (69.4) | 237 (62.5) | 440 (73.7) | <0.001 |