Table 1.
Demographics and Baseline Characteristics by Country/Region
| Total (N=3,359) |
South Korea (n=1,887) |
Taiwan (n=983) |
Hong Kong (n=190) |
Thailand (n=299) |
|
|---|---|---|---|---|---|
| Sex, male, n (%) | 1,996 (59.4) | 1,145 (60.7) | 583 (59.3) | 112 (58.9) | 156 (52.2) |
| Age, years, mean±SD* | 71.7±9.6 | 70.9±9.0 | 73.0±10.1 | 72.9±10.9 | 71.5±10.3 |
| Weight, kg, mean±SD | 65.9±12.4 | 65.8±11.7 | 66.3±12.6 | 64.3±13.3 | 66.5±15.3 |
| Body mass index, kg/m2, mean±SD** | 25.0±3.8 | 24.8±3.5 | 25.3±3.9 | 24.8±4.1 | 25.4±4.6 |
| eGFR, mL/min/1.73 m2, mean±SD* | 62.6±23.8 | 65.8±23.0 | 59.1±24.3 | 55.3±23.3 | 60.1±24.2 |
| CHA2DS2-VASc, mean±SD* | 3.1±1.5 | 3.0±1.4 | 3.1±1.4 | 3.4±1.7 | 3.5±1.6 |
| Modified HAS-BLED, mean±SD | 2.3±1.1 | 2.2±1.0 | 2.3±1.1 | 2.3±1.1 | 2.5±1.1 |
| Type of AF, n (%) | |||||
| Paroxysmal* | 1,509 (45.0) | 658 (34.9) | 607 (62.0) | 85 (44.7) | 159 (53.2) |
| Persistent* | 792 (23.6) | 542 (28.7) | 132 (13.5) | 73 (38.4) | 45 (15.1) |
| Long-standing persistent* | 423 (12.6) | 319 (16.9) | 93 (9.5) | 6 (3.2) | 5 (1.7) |
| Permanent* | 631 (18.8) | 368 (19.5) | 147 (15.0) | 26 (13.7) | 90 (30.1) |
| Diabetes mellitus, n (%) | 999 (29.7) | 534 (28.3) | 305 (31.0) | 67 (35.3) | 93 (31.1) |
| Hypertension, n (%)* | 2,427 (72.3) | 1,335 (70.7) | 706 (71.8) | 135 (71.1) | 251 (83.9) |
| Heart failure, n (%)*,† | 418 (12.4) | 182 (9.6) | 154 (15.7) | 21 (11.1) | 61 (20.4) |
| COPD, n (%)** | 161 (4.8) | 74 (3.9) | 64 (6.5) | 6 (3.2) | 17 (5.7) |
| Peripheral artery disease, n (%)** | 25 (0.7) | 6 (0.3) | 15 (1.5) | 2 (1.1) | 2 (0.7) |
| History of ischemic stroke, n (%)* | 507 (15.1) | 326 (17.3) | 84 (8.5) | 42 (22.1) | 55 (18.4) |
| History of major or CRNM bleeding, n (%)* | 106 (3.2) | 43 (2.3) | 32 (3.3) | 13 (6.8) | 18 (6.0) |
| History of major bleeding, n (%) | 76 (2.3) | 37 (2.0) | 20 (2.0) | 6 (3.2) | 13 (4.3) |
*P value for difference <0.0001, **P value for difference <0.05. †A medical history of heart failure was determined if the patient met one of the following criteria: documented congestive heart failure (CHF) or, if CHF was not reported, documentation of ischemic cardiomyopathy; ejection fraction <40%; frequent dyspnea (≥1/day) without chronic obstructive pulmonary disease and with documented severe valvular heart disease, coronary artery disease post-myocardial infarction, valve replacement, or hypertension treated with ≥3 antihypertensive drugs. AF, atrial fibrillation; CHA2DS2-VASc, Congestive heart failure, Hypertension, Age, Diabetes, Prior Stroke/Transient Ischemic Attack, Vascular disease, and Sex category; COPD, chronic obstructive pulmonary disease; CRNM, clinically relevant nonmajor; eGFR, estimated glomerular filtration rate; HAS-BLED, Hypertension, Abnormal renal and liver function, Stroke, Bleeding history or disposition, Labile international normalized ratio, Elderly, Drugs or alcohol; SD, standard deviation.