Fig. 2.

Representative immunohistochemistry images. (A) p16 expression in histologically normal pancreas; (B) primary tumour expressing p16; (C) primary tumour showing loss of p16 expression; (D) histologically normal pancreas expressing p53; (E) primary tumour with loss of p53; (F) primary tumour showing nuclear accumulation of p53; (G) histologically normal pancreas expressing SMAD4; (H) peritoneal metastasis with expression of SMAD4; (I) primary tumour showing loss of SMAD4; (J) primary tumour with ≤ 10% of cells expressing Ki67; (K) primary tumour expressing Ki67 in 10% to 50% of cells; (L) expression of Ki67 in > 50% of neoplastic cells in an abdominal wall metastasis (Scale bars indicate 100 μm).