Table 2.

Summary results of combined somatic mutations and IHC abnormalities. IHC, immunohistochemistry; MUT, mutations detected by sequencing.

	KRAS	CDKN2A/p16		TP53/p53			SMAD4/SMAD4
	MUT	MUT	Loss IHC	MUT	Nuclear accumulation IHC	Loss IHC	MUT	Loss IHC
N. of patients and %	29/33	17/33	30/35	27/33	27/35	6/35	11/33	25/35
	88%	52%	86%	82%	77%	17%	33%	71%
MUT + IHC combined		33/35		35/35			28/35
		94%		100%			80%