Table 2.
Events of cardiovascular disease in peripheral blood stem cell donors compared with age-, sex- and residence-matched controls.
| New cardiovascular disease after time of donation | PBSC donors | Matched population controls | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N = 1098 | Number of events (%) | Events/1000 person-years | N = 5495 | Number of events | Events/1000 person-years | Hazard ratio | 95% Confidence Interval | P-value | ||
| Any cardiovascular disease | 1038 | 150 (14.5) | 18.1 | 5022 | 755 (15.0) | 19.2 | 0.89 | 0.75 | 1.06 | 0.19 |
| Any cardiovascular disease, except hypertension | 1065 | 113 (10.6) | 11.3 | 5137 | 528 (10.3) | 11.0 | 0.97 | 0.79 | 1.19 | 0.78 |
| Hypertension | 1067 | 95 (8.9) | 9.4 | 5298 | 534 (10.1) | 10.8 | 0.83 | 0.66 | 1.03 | 0.08 |
| Any heart rhythm disease | 1085 | 44 (4.1) | 4.2 | 5408 | 231 (4.3) | 4.5 | 0.92 | 0.67 | 1.27 | 0.61 |
| Atrial Fibrillation | 1091 | 24 (2.2) | 2.3 | 5448 | 153 (2.8) | 2.9 | 0.76 | 0.50 | 1.17 | 0.21 |
| Myocardial infarction and/or Ischaemic heart disease | 1085 | 31 (2.9) | 2.9 | 5430 | 132 (2.5) | 2.6 | 1.07 | 0.72 | 1.58 | 0.74 |
| Myocardial Infarction | 1094 | 19 (1.7) | 1.8 | 5432 | 90 (1.7) | 1.7 | 0.98 | 0.59 | 1.60 | 0.92 |
| Ischaemic Heart Disease | 1085 | 29 (2.7) | 2.8 | 5358 | 126 (2.4) | 2.4 | 0.95 | 0.63 | 1.42 | 0.80 |
| Deep venous thrombosis and/or Pulmonary embolism | 1098 | 17 (1.6) | 1.6 | 5436 | 102 (1.9) | 1.9 | 0.80 | 0.48 | 1.34 | 0.80 |
| Deep venous thrombosis | 1098 | 10 (0.9) | 0.9 | 5447 | 66 (1.2) | 1.3 | 0.73 | 0.38 | 1.42 | 0.35 |
| Pulmonary embolism | 1098 | 7 (0.6) | 0.7 | 5480 | 47 (0.9) | 0.9 | 0.72 | 0.33 | 1.59 | 0.42 |
| Cardiac failure | 1097 | 14 (1.3) | 1.3 | 5464 | 93 (1.7) | 1.8 | 0.73 | 0.41 | 1.28 | 0.26 |
| Cerebrovascular disease | 1094 | 15 (1.4) | 1.4 | 5435 | 121 (2.2) | 2.3 | 0.59 | 0.35 | 1.01 | 0.06 |