TABLE 2.
Demographics and transplant factors of liver transplant recipients with analyzed biopsies (RTCA, HRR, histology).
| EAD (N = 22) | IF (N = 21) | p-value | |
|---|---|---|---|
| Characteristics | |||
| Donor age, [y] (mean ± SD) | 52.45 ± 15.46 | 48.33 ± 15.65 | 0.40 |
| Donor BMI [kg·m −2 ] (mean ± SD) | 28.05 ± 6.29 | 24.60 ± 4.16 | 0.03 |
| Extended criteria donor (ECD)—(N, %) | 18 (81.8%) | 13 (61.9%) | 0.27 |
| Age >65 years | 5 (27.8%) | 2 (15.4%) | |
| BMI >30 kg·m−2 | 4 (22.2%) | 2 (15.4%) | |
| Macrovesicular steatosis >30% | 5 (27.8%) | 1 (7.7%) | |
| ICU-stay >7 days | 2 (11.1%) | 1 (7.7%) | |
| Infection serology | 2 (11.1%) | 1 (7.7%) | |
| Hypernatremia (Na-peak >165 mEq·L−1) | 1 (5.6%) | 1 (7.7%) | |
| Aspartate aminotransferase >90 U·L−1 | 5 (27.8%) | 5 (38.5%) | |
| Alanine aminotransferase >105 U·L−1 | 3 (16.7%) | 4 (30.8%) | |
| Total bilirubin >3 mg·dL−1 | 3 (16.7%) | 4 (30.8%) | |
| LDRI (mean ± SD) | 1.60 ± 0.34 | 1.51 ± 0.28 | 0.33 |
| ET-DRI (mean ± SD) | 1.75 ± 0.42 | 1.60 ± 0.28 | 0.19 |
| Recipient age [y] (median, min-max) | 60.23 ± 10.39 | 59.24 ± 9.29 | 0.48 |
| Recipient BMI [kg·m-2] (mean, SD) | 26.61 ± 5.10 | 25.72 ± 5.26 | 0.59 |
| Prior transplantation (N, %) | 1 (4.6%) | 2 (9.5%) | |
| MELD score (mean ± SD) | 16.41 ± 7.41 | 18.80 ± 8.00 | 0.38 |
| Cold ischemia time [h] (mean ± SD) | 8.41 ± 1.99 | 7.82 ± 2.26 | 0.5 |
| Anhepatic time [min] (mean ± SD) | 61.05 ± 19.54 | 52.29 ± 16.03 | 0.05 |
| Anastomosis time [min] (mean ± SD) | 47.64 ± 9.86 | 40.57 ± 5.92 | 0.02 |
| Length of hospital stay [days] (median, IQR) | 18.5 (15, 23.5) | 19 (14.5, 28.5) | 0.61 |
| ICU stay after LT [days] (median, IQR) | 4.5 (3, 7) | 4 (2.5, 9.5) | 0.81 |
| RTCA score | −0.75 ± 2.27 | 0.70 ± 2.08 | 0.01 |
| High-resolution respirometry | |||
| OXPHOS capacity S P [pmol·s−1·mg wet mass-1] | 40.76 ± 16.26 | 38.83 ± 11.19 | 0.94 |
| Cytochrome c control efficiency, 1-S P /S Pc | 0.17 ± 0.12 | 0.11 ± 0.09 | 0.12 |
| P-L control efficiency, 1-S L /S P | 0.70 ± 0.08 | 0.76 ± 0.06 | 0.02 |
| Histology | 2.52 ± 0.68 | 2.85 ± 0.49 | 0.06 |
| Necrosis | 0.41 ± 0.96 | 0.33 ± 0.73 | 0.87 |
| Steatosis | 0.64 ± 0.85 | 0.43 ± 0.60 | 0.61 |
| Inflammation | 0.65 ± 0.59 | 0.30 ± 0.47 | 0.08 |
| Fibrosis | none | none | n.a |
| Vasculitis | 0.20 ± 0.41 | 0.20 ± 0.41 | 1.000 |
Statistically significant differences are bold.