Table 1.

Description of the main clinical and biological parameters of the 470 patients with MIS-C during hospitalization (initial flare) and the different treatments used.

	Any treatment	IVIG only	VIG and glucocorticoids	Glucocorticoids only	IVIG, glucocorticoids and a biologic	Glucocorticoids and a biologic
	(N = 470)	(N = 57)	(N = 223)	(N = 50)	(N = 8)	(N = 6)
Demographic characteristics
Male sex—no. (%)	276 (58.7)	29 (51)	136 (61.0)	28 (56.0%)	4 (50)	3 (50)
Age—year
Median (IQR)	8.87 (5.2–11.7)	7.5 (3.9–11.1)	7.46 (3.9–11.1)	9.96 (6.04–11.96)	9.0 (5.9–13.5)	10.2 (6.7–10.6)
Range	0.1–24.4	0.3–17.0	0.3–17	1.6–17.6	0.9–20.9	3.6–12.8
Clinical and cardiac characteristics
Troponin level max
No. of patients	256	33	173	30	6	3
Median (IQR)—ng/L	95 (28.0–524.0)	646 (189–36,000)	89 (27.0–386.0)	52.5 (18.5–228.7)	90.5 (66–112)	95 (55–114)
B-type natriuretic peptide level max
No. of patients	11	5	6	NC	NC	NC
Median (IQR)—ng/L	26,597.0 (2,230–207,9100)	26,597 (2,600–63 141)	20,269 (977.7–113,680)
N-terminal pro–B-type natriuretic peptide level max
No. of patients	199	24	129	28	6	5
Median (IQR)—ng/L	4,135 (1,677–13,245)	5,507 (2,036–30,133)	4,068 (1,600–10,478)	4,030.5 (1,519–13,811.5)	18,832 (4,830–20,482)	7,444 (5,016–9,735)
LVEF <55% during hospitalization—no. (total)	27 (46)		19 (33)	1 (3)	3 (5)	3 (5)
Interventions
Vasopressors—no./total (%)	7/385 (1.8)	6/57 (10.5)	34/223 (15.2)	1/49 (2)	0/8 (0)	0/6 (0)
Extracorporeal membrane oxygenation—no./total (%)	1/60 (1.7)	0/21 (0)	1/31 (3.2)	2/2 (100)	0/2 (0)	0/2 (0)
Discharged alive—no. (%)	470 (100)	57 (100)	223 (100)	50 (100)	8 (100)	6 (100)
Median hospital length of stay among survivors (IQR)—days	7 (5.2–10.0)	8 (6–12)	7 (5–10)	8.0 (4.2–10.0)	13 (10.7–16.2)	9.5 (9–12.2)
Died—no. (%)	0 (0)	0 (0)	0	0 (0)	0 (0)	0 (0) A12:A7:G25

LVEF, left ventricular ejection function; Max, maximum value during hospitalization.

Four patients received anakinra alone or after IVIG but without corticosteroids. These four patients were not represented.