Table 2.
Cox proportional hazard models (multivariate analyses) for overall survival of patients aged ≥70 years with PD-L1 TPS ≥ 50% treated with ICI monotherapy (N = 131).
| Characteristics | No of patients (%) |
Overall survival (months) |
Multivariate | |
|---|---|---|---|---|
| HR (95% CI) | P-value | |||
| Age <75 years ≥75 years |
51 (39) 80 (61) |
27.7 23.8 |
1.02 (0.63–1.65) reference |
0.923 |
| Sex female male |
24 (18) 107 (82) |
Not reached 23.9 |
0.50 (0.23–1.06) reference |
0.070 |
| Smoking status Current or former smoker Never |
118 (90) 13 (10) |
27.7 16.5 |
0.36 (0.16–0.78) reference |
0.010 |
| ECOG PS 0 1 |
50 (38) 81 (62) |
26.1 23.8 |
1.02 (0.63–1.66) reference |
0.939 |
| Histology Squamous cell carcinoma Non-squamous cell carcinoma |
41 (31) 90 (69) |
18.3 27.7 |
0.76 (0.46–1.25) reference |
0.273 |
| PD-L1 status 50–89% 90–100% |
75 (57) 56 (43) |
20.9 25.2 |
1.00 (0.62–1.62) reference |
0.939 |
| Stage IVA or IVB Recurrence |
95 (73) 36 (27) |
23.9 29.8 |
0.67 (0.39–1.17) reference |
0.164 |
OS, overall survival; ICI, immune checkpoint inhibitor; ECOG PS, Eastern Cooperative Oncology Group Performance Status; PD-L1, programmed death ligand 1; TPS, tumor proportion score; HR, hazard risk; CI, confidence interval.