Table 3.
Cox proportional hazard models (multivariate analyses) for overall survival in patients ≥70 years old with PD-L1 TPS ≥ 50% treated with combination therapy of ICI and chemotherapy (N = 68).
| Characteristics | No of patients (%) |
Overall survival (months) |
Multivariate | |
|---|---|---|---|---|
| HR (95% CI) | P-value | |||
| Age <75 years ≥75 years |
49 (71) 19 (29) |
Not reached 34.2 |
2.20 (0.95–5.09) reference |
0.066 |
| Sex female male |
18 (25) 50 (75) |
23.1 42.2 |
2.75 (0.75–10.03) reference |
0.126 |
| Smoking status Current or former smoker Never |
54 (81) 14 (19) |
42.2 23.1 |
1.07 (0.24–4.70) reference |
0.929 |
| ECOG PS 0 1 |
25 (37) 43 (63) |
Not reached 34.2 |
3.84 (1.44–10.20) reference |
0.007 |
| Histology Squamous cell carcinoma Non-squamous cell carcinoma |
20 (29) 48 (71) |
18.5 Not reached |
0.17 (0.06–0.44) reference |
<0.001 |
| PD-L1 status 50%–89% ≥90% |
47 (68) 21 (32) |
42.2 Not reached |
0.47 (0.19–1.13) reference |
0.091 |
| Stage IVA or IVB Recurrence |
60 (88) 8 (12) |
42.2 Not reached |
0.35 (0.09–1.38) reference |
0.132 |
OS, overall survival; ICI, immune checkpoint inhibitor; ECOG PS, Eastern Cooperative Oncology Group Performance Status; PD-L1, programmed death ligand 1; TPS, tumor proportion score; HR, hazard risk; CI, confidence interval.