Fig. 2.

Cell–cell communication analysis between T cells and malignant cells in tumor. (A) Bar plot shows the total number of the inferred cell–cell communication networks among nLung, tLung, mLN, and mBrain groups. (B) Circle plots summarize the number of differentially expressed interactions between mLN and tLung or mBrain and tLung groups. (C) Top representative differentially expressed ligand–receptor signaling pathways among the four groups. (D) Scatterplot shows common or specific signaling pathways between T cells and malignant cells in the mLN (x-axis) and mBrain (y-axis) groups. (E, F) Visualization of cell–cell communication between different cell groups for incoming and outgoing signals.