Fig. 4.

Cell–cell communication analysis between myeloid and malignant cells in tumor. (A) Bar plot showing the total number of the inferred cell–cell communication networks among nLung, tLung, mLN, and mBrain groups. (B) Circle plots summarize the number of differential expressed interactions between mLN and tLung or between mBrain and tLung groups. (C) Top representative differentially expressed L-R signaling pathways among the four groups. (D) Scatterplot shows common or specific signal pathways between myeloid and malignant cells in mLN (x-axis) and mBrain (y-axis) groups. (E, F) Detailed visualization of cell–cell communication between different cell groups for incoming and outgoing signals.