Table 1.
Demographic data and baseline characteristics of animals
| Totala (n = 18) | FCVa (n = 9) | PCVa (n = 9) | Estimate with 95% CIb | p-valuec | |
|---|---|---|---|---|---|
| Demographic data | |||||
| Weight | 54 (51–67) | 52 (49–57) | 56 (51–70) | − 5 (− 21 to 2) | 0.1840 |
| Sex [female] | 5/18 (27.8%) | 3/9 (33.3%) | 2/9 (22.2%) | 1 | |
| Haemodynamic parameters | |||||
| HR [/min] | 70 (66–76) | 67 (65–74) | 72 (69–76) | − 5 (− 18 to 4) | 0.1995 |
| MAP [mmHg] | 79 (74–84) | 81 (75–85) | 77 (71–81) | 4 (− 4 to 12) | 0.2689 |
| CVP [mmHg] | 13 (11–16) | 14 (11–16) | 12 (12–13) | 1 (− 4 to 4) | 0.8239 |
| MPAP [mmHg] | 26 (24–28) | 27 (25–28) | 25 (24–27) | 1 (− 5 to 4) | 0.6258 |
| PCWP [mmHg] | 15 (13–17) | 15 (14–17) | 14 (13–16) | 1 (− 4 to 3) | 0.7216 |
| CI [l/min/m2] | 5.8 (4.8–6.8) | 5.6 (4.7–6.9) | 5.9 (5.3–6.5) | − 0.6 (− 1.9 to 1.0) | 0.4363 |
| PVRI [dyn·s/cm5/m2] | 130 (110–177) | 145 (113–208) | 125 (108–151) | 26 (− 23 to 89) | 0.3865 |
| SVRI [dyn·s/cm5/m2] | 847 (670–1031) | 1014 (841–1050) | 734 (624–875) | 228 (− 23 to 533) | 0.0503 |
| Respiratory parameters | |||||
| RR [/min] | 35 (32–39) | 34 (32–39) | 36 (32–38) | 0 (− 6 to 6) | 0.9292 |
| VT [ml/kg] | 7.0 (7.0–7.1) | 7.0 (7.0–7.1) | 7.0 (7.0–7.1) | 0.0 (− 0.1 to 0.1) | 0.8945 |
| MV [l/min] | 15.1 (12.8–16.0) | 14.2 (11.4–15.8) | 15.5 (14.1–16.0) | − 1.6 (− 4.7 to 1.0) | 0.3770 |
| Ppeak [cmH2O] | 22 (21–25) | 22 (21–23) | 22 (21–28) | − 2 (− 7 to 2) | 0.4227 |
| PEEP [cmH2O] | 5 | 5 | 5 | ||
| ΔP [cmH2O] | 17 (16–20) | 17 (16–18) | 17 (16–23) | − 2 (− 7 to 2) | 0.4227 |
| C [ml/cmH2O] | 36.6 (32.6–43.1) | 37.0 (33.2–39.6) | 35.8 (32.4–49.5) | − 1.4 (− 12.4 to 6.3) | 0.8252 |
| CCalc [ml/cmH2O] | 23.2 (20.8–24.3) | 23.1 (20.6–25.6) | 23.3 (21.3–24.0) | 0 (− 3.8 to 4.6) | 0.9647 |
| R [cmH2O·s/l] | 6.8 (6.6–7.3) | 6.8 (6.7–7) | 6.8 (6.6–7.4) | 0.0 (− 1.7 to 0.6) | 1 |
| MP [J/min] | 22.7 (18.1–26.8) | 22.3 (16.6–24.6) | 24.3 (21.0–31.3) | − 4.9 (− 13.4 to 1.8) | 0.2224 |
| PaCO2 [mmHg] | 43 (42–45) | 43 (41–45) | 43 (42–45) | 0 (− 3 to 3) | 1 |
| PaO2 [mmHg] | 116 (112–125) | 125 (123–132) | 114 (105–115) | 15 (6 to 22) | 0.017* |
| Metabolic parameters | |||||
| pH | 7.38 (7.36–7.40) | 7.37 (7.34–7.40) | 7.39 (7.38–7.40) | − 0.02 (− 0.05 to 0.02) | 0.4265 |
| Hb [mg/dl] | 8.8 (8.5–9.12) | 8.9 (8.5–9.3) | 8.6 (8.5–8.9) | 0.2 (− 0.5 to 0.8) | 0.6243 |
| Lac [mg/dl] | 12 (8.5–16) | 12 (10–13) | 12 (7–17) | 0 (− 5 to 5) | 1 |
| SvO2 [%] | 62 (56–63) | 60 (56–63) | 63 (57–63) | − 2 (− 7 to 3) | 0.5457 |
C displayed compliance from the ventilator, CCalc calculated static compliance, CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, Hb arterial hemoglobin level, HR heart rate, Lac arterial lactate level, MAP mean arterial pressure, MP mechanical power, MPAP mean pulmonary arterial pressure, MV respiratory minute volume, PaCO2 arterial partial pressure of carbon dioxide, PaO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, PEEP positive end-expiratory pressure, pH arterial potential of hydrogen, Ppeak peak pressure, PVRI pulmonary vascular resistance index, R resistance, RR respiratory rate, SvO2 mixed venous oxygen saturation, SVRI systemic vascular resistance index, VT tidal volume, ΔP driving pressure (= peak pressure – positive end-expiratory pressure)
aBinary data are presented as no./total no. (%), continuous data as medians (25th to 75th percentile)
bOdds ratios for binary variables and estimated median difference for continuous variables
cAssessed by Fisher’s exact test for categorical variables and Wilcoxon rank sum test for continuous variables, significant differences (p < 0.05) are marked with an asterisk