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. 2024 Mar 7;9:64. doi: 10.1038/s41392-024-01772-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — CPT1A preserves the antioxidant state and restricts phospholipid polyunsaturated fatty acid production in lung cancer cells. a–c Analysis of cellular redox state in H1299-shNC/shCPT1A cells. Levels of NADPH (a), GSH (b) and GSSG (c) calculated by colorimetry or LC-MS. Data represent the mean ± s.d.; n = 3 samples. d–f Analysis of fatty acid in H1299-shNC/shCPT1A cells. Levels of free fatty acid (d), adrenic acid (e) and arachidomic acid (f) calculated by LC-MS. Data represent the mean ± s.d.; n = 3 samples. g–i Analysis of PUFA-PLs in H1299-shNC/shCPT1A cells. KEGG analysis of the untargeted lipidomic data (g), volcano plots of lipid species (h) and levels of polyunsaturated fatty acids with adrenic acid or arachidomic acid branches (i) detected by LC-MS. Data represent the mean ± s.d.; n = 3 samples. *P < 0.05, **P < 0.01, ***P < 0.001; ns: not significant. The statistical analysis was performed using a two-tailed Student’s t-test