Table 2.

Differential functional resting-state connectivity within SPQ-responders and non-responders (ROI-to-ROI and Seed-to-Voxel).

Analyses discovery sample								Cross-team replication									Cross-site replication
ROI-to-ROI						T	pFDR								T	pFDR								T	pFDR
t-contrast: resp > non-resp
Hippocampus L ⟷		Hippocampus R				3.77	<0.01	Hippocampus L ⟷			Hippocampus R				3.83	<0.01	Middle frontal gyrus, medial part R ⟷			Middle frontal gyrus, orbital part R				3.53	<0.05
								Inferior frontal gyrus, pars opercularis L ⟷			Inferior frontal gyrus, pars triangularis R				3.32	<0.05	Insula L ⟷			Thalamus R				− 3.72	<0.05
t-contrast: non-resp > resp
Hippocampus L ⟷		Inferior frontal gyrus, pars orbitalis				3.38	<0.05	Hippocampus L ⟷			Inferior frontal gyrus, pars orbitalis				3.65	<0.05
Seed-to-Voxel	Side	k	x	y	z	T	pFDR			Side	k	x	y	z	T	pFDR		Side	x	y	z			T	pFDR
Amygdala
t-contrast: resp > non-resp
Cluster 1:		174	6	−88	6	4.85	<0.001	Cluster 1:			137	6	−86	6	3.20	<0.05	No differential connectivity
Calcarine	R	99						Calcarine		R	88
Lingual gyrus	R	46						Lingual gyrus		R	35
	L	17						Calcarine		L	12
Calcarine	L	11						Lingual gyrus		L	2
AAL not-labeled	--	1
Cluster 2:		151	−10	−42	−12	5.27	<0.001
Cerebellum 4/5	L	105
Lingual gyrus	L	25
Fusiform gyrus	L	14
Vermis 4/5	--	5
Cerebellum 3	L	2
Cluster 3:		108	16	−52	−10	4.93	<0.001
Cerebellum 4/5	R	58
Fusiform gyrus	R	24
Lingual gyrus	R	17
Cerebellum 6	R	9
Seed-to-Voxel	Side	k	x	y	z	T	pFDR			Side	k	x	y	z	T	pFDR		Side	x	y	z			T	pFDR
t-contrast: non-resp > resp
No differential connectivity																	No differential connectivity
Seed-to-Voxel	Side	k	x	y	z	T	pFDR			Side	k	x	y	z	T	pFDR		Side	x	y	z			T	pFDR
Anterior cingulate cortex
t-contrast: resp > non-resp
Cluster 1:		158	−14	28	10	6.32	<0.001	Cluster 1:			175	−12	28	8	3.2	<0.001	No differential connectivity
Anterior cingulate cortex	L							Anterior cingulate cortex		L	24
	R									R	6
Mid cingulate cortex	L							Mid cingulate cortex		L	3
	R									R	3
AAL not-labeled	--							AAL not-labeled		--	139
t-contrast: non-resp > resp
No differential connectivity								No differential connectivity									No differential connectivity
Hippocampus
t-contrast: resp > non-resp
Cluster 1:		102	26	−78	−14	4.00	<0.001	Cluster 1:			118	26	−78	−14	3.2	<0.05	No differential connectivity
Lingual gyrus	R	72						Lingual gyrus			95
Fusiform gyrus	R	25						Fusiform gyrus			18
Cerebellum 6	R	5						Cerebelum 6			5
t-contrast: non-resp > resp
No differential connectivity								No differential connectivity									No differential connectivity

FDR false discovery rate, k number of voxels per cluster/region, non-resp non-responder, resp responder, ROI region of interest, SPQ spider phobia questionnaire, x, y, z, MNI coordinates.