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. 2024 Mar 7;15:2107. doi: 10.1038/s41467-024-46195-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In IA, synovial IL1B^hi macrophages, likely originating from peripheral IL1B^hi CD14+ monocytes, communicate with exhausted CD8⁺ T cells through the CCR1-CCL5/CCL3 and CXCL10-CXCR3 axes (right). This interaction may play a key role in PD-1-IA pathogenesis but not in RA (left). RA rheumatoid arthritis, IA inflammatory arthritis, MΦ macrophage, Mono monocyte, Tex exausted T cell, CTL cytotoxic T cell.