Table 1.

The exclusion criteria for rats selected for the study.

Parameters	Observation
General appearance	Dehydration, decreased body weight, missing anatomy, abnormal posture, hypothermia, fractured appendage, swelling, tissue masses
Skin and fur	Discoloration, urine stain, pallor, redness, cyanosis, icterus, wound, sore, abscess, ulcer, alopecia, ruffled fur
Eyes	Exophthalmos, microphthalmia, ptosis, reddened eye, lacrimation, discharge, opacity
Nose, mouth, and head	Head tilted, nasal discharge, malocclusion, salivation
Respiration	Sneezing, dyspnoea, tachypnoea, rales
Urine	Discolouration, blood in urine, polyuria, anuria
Faeces	Discolouration, blood in the faeces, softness/diarrhoea
Locomotor	Hyperactivity, coma, ataxia, circling, muscle tremors