Table 3.

Evaluation of sperm concentration, total sperm motility, free testosterone level, FSH and LH of control group and other groups treated with oral administration of sofosbuvir and/or its combination with ribavirin in adult male albino rats.

	G1 (control group)	G2 (Sofosbuvir)	G3 (Sofosbuvir + Ribavirin)
Sperm concentration (million/ml)	182.86 ± 6.8	181.86 ± 9.84	181.6 ± 10.55
Total sperm motility percent (%)	78.29 ± 4.15	55.29 ± 7.67−a	57.43 ± 6.02−a
Testosterone (pg/ml)	0.27 ± 0.06	0.25 ± 0.09	0.36 ± 0.08+b
FSH (mIU/ml)	0.02 ± 0.01	0.03 ± 0.02	0.03 ± 0.02
LH (mIU/ml)	0.004 ± 0.002	0.003 ± 0.003	0.003 ± 0.001

The results presented as Mean ± S.D. of seven rats.

^asignificantly different from control group at (p < 0. 05).

^bsignificantly different from G2 (Sofosbuvir group) at (p < 0. 05).