Table 4.

Evaluation of thyroid hormones, insulin, cortisol and AFP of control group and other groups treated with oral administration of sofosbuvir and/or its combination with ribavirin in adult male albino rats.

	G1 (control group)	G2 (Sofosbuvir)	G3 (Sofosbuvir + Ribavirin)
T3 (pg/ml)	2.19 ± 0.22	2.36 ± 0.23	2.18 ± 0.08
T4 (ng/dl)	0.51 ± 0.06	0.37 ± 0.08−a	0.32 ± 0.09−a
TSH (uIU/ml)	0.007 ± 0.007	0.0012 ± 0.001−a	0.001 ± 0.001−a
Insulin (uIU/ml)	93.14 ± 8.55	72.57 ± 7.35−a	77.71 ± 8.24−a
Cortisol (ng/ml)	0.39 ± 0.09	0.55 ± 0.09+a	0.48 ± 0.11
AFP (ng/ml)	0.7 ± 0.1	0.49 ± 0.08−a	0.44 ± 0.12−a

The results presented Mean ± S.D. of seven rats.

^asignificantly different from control group at (p < 0. 05).

bsignificantly different from G2 (Sofosbuvir group) at (p < 0. 05).