Table 5.
detection of serobiochemical parameters of control group and other groups treated with oral administration of sofosbuvir and/or its combination with ribavirin in adult male albino rats.
| Groups | G1 (control group) | G2 (Sofosbuvir ) | G3 (Sofosbuvir + Ribavirin ) |
|---|---|---|---|
| ALP (U/L) | 270.0 ± 15.77 | 283.86 ± 29.24 | 139.29 ± 10.81−a−b |
| GOT (U/L) | 84.29 ± 10.13 | 96.86 ± 4.18+a | 77.57 ± 14.99−b |
| GPT (U/L) | 24.29 ± 4.68 | 26.57 ± 7.02 | 17.57 ± 4.31−a−b |
| Creatinine (mg/dl) | 0.58 ± 0.07 | 0.57 ± 0.08 | 0.61 ± 0.06 |
| Urea (mg/dl) | 47.14 ± 2.61 | 45.29 ± 1.6 | 45.29 ± 2.36 |
| Uric acid (mg/dl) | 1.47 ± 0.21 | 1.59 ± 0.28 | 1.46 ± 0.45 |
| Triglyceride (mg/dl) | 107.29 ± 14.84 | 121.7 ± 23.64 | 143.86 ± 14.42+a+b |
| Cholesterol (mg/dl) | 67.28 ± 5.28 | 69 ± 18.31 | 70 ± 13.9 |
| Lipase (U/L) | 13.0 ± 1.41 | 17.71 ± 0.95+a | 15.71 ± 1.79+a−b |
| ADA (U/L) | 47.02 ± 0.58 | 40.86 ± 0.81−a | 45.57 ± 4.24+b |
The results presented Mean ± S.D. of seven rats.
asignificantly different from control group at (p < 0. 05).
bsignificantly different from G2 (Sofosbuvir group) at (p < 0. 05).