Table 1.
Baseline characteristics of the patients in the derivation and validation cohorts
| Characteristic | Total (N=410) | Derivation cohort (N=290) | Validation cohort (N=120) | P |
|---|---|---|---|---|
| Age (years) | 34(28, 45) | 34(28, 44) | 34(27, 47) | 0.569 |
| Men, n (%) | 133(32.44) | 93(32.07) | 40(33.33) | 0.803 |
| BMI (kg/m2) | 22.50(20.50, 24.96) | 22.42(20.70, 25.13) | 22.50(20.30, 24.30) | 0.552 |
| Hypertension, n (%) | 135(32.93) | 98(33.79) | 37(30.83) | 0.562 |
| UPE (g/d) | 0.182 | |||
| <1 | 261(63.66) | 185(63.79) | 76(63.33) | |
| 1-3.5 | 118(28.78) | 79(27.24) | 39(32.50) | |
| ≥3.5 | 31(7.56) | 26(8.97) | 5(4.17) | |
| Hematuria (RBCs/ul) | 54.00(20.00, 149.25) | 54.00(18.00, 150.00) | 61.00(22.25, 146.25) | 0.341 |
| Serum creatinine (μmol/L) | 89.00(71.75, 125.00) | 89.00(71.00, 125.00) | 89.00(73.00, 121.00) | 0.632 |
| Serum cystatin C | 1.00(0.82, 1.37) | 0.97(0.82, 1.36) | 1.02(0.84, 1.39) | 0.504 |
| Serum albumin (g/L) | 36.40(32.70, 40.02) | 36.75(32.78, 40.30) | 35.60(32.60, 39.48) | 0.272 |
| Hs-CRP (mg/L) | 0.78(0.32, 1.99) | 0.80(0.31, 1.99) | 0.66(0.33, 2.01) | 0.936 |
| eGFRcr-cys (mL/min/1.73m2) | 80.44(50.48, 103.30) | 81.27(50.30, 104.00) | 78.60(54.69, 101.44) | 0.552 |
| Serum IgG (g/L) | 11.80(9.55, 13.80) | 11.90(9.77, 13.83) | 11.60(9.35, 13.48) | 0.307 |
| Serum IgA (g/L) | 3.16(2.51, 3.99) | 3.15(2.49, 3.98) | 3.18(2.60, 4.07) | 0.744 |
| Serum IgM (g/L) | 1.08(0.79, 1.47) | 1.08(0.80, 1.43) | 1.04(0.76, 1.55) | 0.938 |
| Serum C3 (mg/L) | 1030.00(916.75, 1170.00) | 1040.00(920.00, 1170.00) | 1005(895, 1178) | 0.785 |
| Serum C4 (mg/L) | 246.00(201.00, 305.25) | 247.50(203.00, 305.00) | 243(198, 308) | 0.809 |
| Oxford MEST-C, n (%) | ||||
| M1 | 385(93.90) | 270(93.10) | 115(95.8) | 0.293 |
| E1 | 81(19.80) | 58(20.00) | 23(19.2) | 0.874 |
| S1 | 196(47.80) | 137(47.20) | 59(49.2) | 0.723 |
| T1/2 | 124(30.20) | 82(28.30) | 42(35.0) | 0.177 |
| C1/2 | 221(53.90) | 149(51.40) | 72(60.0) | 0.111 |
Results are presented as mean SD, median (interquartile range), or number (percentage).
Groups were compared by using Kruskal-Wallis or F test
BMI body mass index; UPE urinary protein excretion; eGFR estimated glomerular filtration rate; hs-CRP high-sensitivity C-reactive protein; MEST-C, M mesangial hypercellularity; E endocapillary hypercellularity; S segmental glomerulosclerosis; T interstitial fibrosis/tubular atrophy; C crescent formation.