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. 2024 Mar 7;15:2100. doi: 10.1038/s41467-024-46322-8

Fig. 4. Functional ability of Mo primed with SARS-CoV-2 proteins to activate CD8 + T cells in vitro and comparison with specific CD8 + T cell responses in critical COVID-19 patients.

Fig. 4

Fold change in proportions of CD8 + T cells expressing CD107a (A) (p = 0.0010) and IFNγ (B) (p = 0.0391; 0.0031) either after 3 days of culture with allogeneic Mo (left panels) primed with DMSO or S1 (orange), NP (purple), Poly I:C (PIC; pink), Flagellin (FLAG, khaki) (n = 8) or induced directly by S1 (green) or NP (purple) peptide stimulation in PB (n = 14) (middle panel) and BAL (n = 11) (right panel) of severe COVID-19 patients. Data are represented as box and whiskers with bars representing maximum and minimum values and with median highlighted as a line. Statistical significance was calculated using a two-tailed Wilcoxon test: *p < 0.05, **p < 0.01, ***p < 0.001.