Table 4.
Effect of the DEME on biochemical parameters in STZ Induced Rats.
| Biochemical Markers (Unit) |
Normal Control |
Negative Control |
Standard drug (Glibenclamide) |
DEME 200mg/kg |
DEME 400mg/kg |
|---|---|---|---|---|---|
| AST (U/L) | 110.3 ± 2.7 | 261.2 ± 47.2a | 124.7 ± 11.97g | 150.7 ± 9.5h | 132.5 ± 38g |
| ALT (U/L) | 50.17 ± 3.4 | 239 ± 44a | 66.83 ± 6.3f | 76 ± 6.2f | 61.17 ± 6.9f |
| Glucose (mmol/L) | 6.37 ± 0.85 | 44.02 ± 5.19a | 20.37 ±4.18g | 24.8 ± 5.13h | 16.83 ± 3.14f |
| LDH (U/L) | 1334 ± 132 | 2222 ± 116.5b | 1357 ± 139.7g | 1435 ± 18h | 1441 ± 223h |
| TC (mm /L) | 66.28 ± 2.7 | 40.36 ± 27b | 59.7 ± 4.4h | 62.42 ± 4.04g | 59.20 ± 6.12h |
| T. Bil (µmol/L) | 0.587 ± 0.09 | 2.31 ± 0.34b | 0.9± 0.25g | 1.03 ± 0.27g | 0.983 ± 0.33h |
| Insulin µg/L | 2.71 ± 0.01 | 2.44 ± 0.001c | 3. 55 0.016h | 2.45 ± 0.004 | 3.53± 0.02h |
Values are mean ± S.E.M of six animals. Superscript represents the significant by ANOVA, followed with Tukey’s multiple comparison test, aP<0.001, bP<0.01, cP<0.05, is the significant induction of diabetes in the negative diabetic control group when compared to the normal control animal group. fP<0.001, gP<0.01, hP<0.05, is the significant improvement from the diabetic conditions on comparison of negative control (STZ injected) animals with the treated animal groups such as standard drug, DEME 200 and 400 mg/kg respectively.