FIGURE 2.

(A) Schematic representation of the RET protein. The epigenetically primed regions of RET proto‐oncogene, which span the E‐4 and E‐5 (B) and E‐15 and E‐16 (C), represent the predicted binding of different activating transcription factors. The degree of correlation (* r ≥ 0.4 or r ≤ ‐0.4, p < 0.05) was evaluated between the expression of RET with essential genes involved in the formation of KMT2A‐complex (D), the activator or cohesion complex of enhancer assemblies (E), or establishing the enhancer‐mediator complexes (F).