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. 2024 Feb 6;4(2):100707. doi: 10.1016/j.crmeth.2024.100707

Figure 5.

Figure 5

PolyAMiner-Bulk analysis of the bulk RNA-seq benchmarking dataset of HEK293 cells with and without siRNA-mediated knockdown of RBM17

(A) Volcano plot of differentially expressed core APA factors.

(B) Volcano plot of differential APA genes.

(C) Representative differential APA gene with a positive PolyAIndex, suggesting 3′ UTR elongation.

(D) Representative differential APA gene with a negative PolyAIndex, suggesting 3′ UTR shortening.