Table 2.

Differentiation of syndromes with Silvery hair

Elejalde	Chediak-Higashi	Griscelli
Normal	Phagocytic immunodeficiency	Phagocytic immunodeficiency	Immunodeficiency
Clumps of melanin in irregular patterns	Regularly arranged clumps of melanin	Clumps of melanin in irregular patterns	Hair
Melanosomes in different stages in melanocytes	Large melanosomes in melanocytes and keratinocytes	Mature melanosomes in melanocytes and sometimes in keratinocytes	Skin
Normal	Bleeding tendencies	Normal	Bleeding
Severe neurologic impairment (eg, seizures, severe hypotonia, mental retardation)	Progressive sensory or motor neurological defect	Failure of decussation of the optic and auditory nerves	Neurological