Table 1.
Comparison of plasma marbofloxacin concentrations following single-dose oral administration (5.00 mg kg-1 body weight) in Group I (non-pre-treated; n = 8) and Group II (pre-treated with alpha-1-monolaurin; n = 8)
| Time after administration (hr) | Concentrations (µg mL -1 ) | |
|---|---|---|
| Group I | Group II | |
| 0.083 | 0.42 ± 0.06 | 0.38 ± 0.07 |
| 0.25 | 0.61 ± 0.18 | 0.82 ± 0.18 |
| 0.5 | 0.97 ± 0.18 | 1.44 ± 0.29 |
| 1 | 1.61 ± 0.21 | 2.19 ± 0.29* |
| 2 | 1.77 ± 0.14 | 2.09 ± 0.21* |
| 4 | 0.97 ± 0.13 | 1.20 ± 0.10 |
| 8 | 0.59 ± 0.06 | 0.69 ± 0.06 |
| 12 | 0.37 ± 0.06 | 0.33 ± 0.02 |
| 24 | 0.10 ± 0.04 | 0.18 ± 0.02* |
| 36 | ND | ND |
| 48 | ND | ND |
ND: Not detected.
* indicates statistically significant difference at p ≤ 0.05.