Table 2.
Comparison of pharmacokinetic (PK) parameters of marbofloxacin following single-dose oral administration (5.00 mg kg-1 body weight) in Group I (non-pre-treated; n = 8) and Group II (pre-treated with alpha-1-monolaurin; n = 8)
| Parameters | Values of PK parameters | |
|---|---|---|
| Group I | Group II | |
| Cl B ( L kg-1 per hr) | 0.36 ± 0.02 | 0.30 ± 0.02† |
| C max (g mL -1 ) | 1.95 ± 0.13 | 2.43 ± 0.22* |
| T max (hr) | 1.63 ± 0.19 | 1.38 ± 0.183 |
| (per hr) | 0.12 ± 0.01 | 0.11 ± 0.004 |
| t 1/2 (hr) | 6.22 ± 0.48 | 6.47 ± 0.25 |
| AUC (g hr mL -1 ) | 14.48 ± 1.29 | 17.32 ± 1.51† |
| AUMC (g hr 2 mL -1 ) | 119.83 ± 12.56 | 158.16 ± 18.87* |
| MRT (hr) | 8.28 ± 0.53 | 9.03 ± 0.48 |
| V d(area) (L kg -1 ) | 3.26 ± 0.35 | 2.83 ± 0.24 |
Cmax: Maximum plasma concentration; Tmax: Time at which Cmax was observed; β: Elimination rate constant; t1/2β: Terminal half-life; AUC: Area under the curve; AUMC: Area under first moment of the plasma drug concentration curve; MRT: Mean resident time; Vd(area): Apparent volume of distribution (scaled by bio-availability); ClB: Total body clearance (scaled by bioavailability).
*, † indicate statistically significant difference at p ≤ 0.05 andp ≤ 0.01, respectively.