Table 2.
Sources of exosomes and their roles in NOD-like receptor family pyrin domain containing 3 inflammasome regulation
|
Exosomes source
|
Pivotal molecules
|
Role of the exosomes
|
Ref.
|
| Stem cell | miR-378a-5p | Inhibiting NLRP3 inflammasome activation | [71] |
| Stem cell | miR-539-5p | Inhibiting NLRP3 inflammasome activation | [72] |
| Stem cell | NA | Inhibiting NLRP3 inflammasome activation | [73] |
| Stem cell | miR-17 | Inhibiting NLRP3 inflammasome activation by targeting TXNIP | [106] |
| Stem cell | NA | Inhibiting NLRP3 inflammasome activation by down-regulating ROS levels | [107] |
| Stem cell | NA | Inhibiting TLR4-NLRP3-mediated pyroptosis | [108] |
| Plasma | NA | Inhibiting pyroptosis through the TLR4/NF-κB pathway | [109] |
| Stem cell | NA | Inhibiting NLRP3 inflammasome-mediated pyroptosis by promoting AMPK-dependent autophagic flux | [110] |
| Stem cell | circHIPK3 | Inhibiting pyroptosis by down-regulating miR-421 to increase FOXO3A expression | [111] |
| Stem cell | miRNA Let-7 | Inhibiting NLRP3 inflammasome activation by down-regulating ROS levels | [112] |
| Stem cell | miR-188-3p | Targeting NLRP3 | [113] |
| Stem cell | NA | Inhibiting the tumor suppressor Rb1-mediated NLRP3 inflammasome | [114] |
| Stem cell | NA | Inhibiting pyroptosis through the TLR4 pathway | [115] |
| Cancer cells | miR-21 | Repressing PTEN and BRCC3 to facilitate NLRP3 phosphorylation | [116] |
| Stem cell | circ_003564 | Attenuating inflammasome-related pyroptosis | [117] |
| Stem cell | miR-100-5p | Inhibiting the FOXO3A/NLRP3 pathway | [118] |
| Stem cell | miR-17-5p | Suppressing TXNIP-NLRP3 inflammasome | [119] |
| Pericyte | circEhmt1 | Upregulating NFIA levels to suppress NLRP3-mediated inflammasome formation | [120] |
| B cells | miR-BART15 | Targeting the miR-223 binding site in the NLRP3 3′-untranslated region | [121] |
| Stem cell | NA | Suppressing NLRP3 inflammasome activation | [122] |
| Stem cell | NA | Suppressing NLRP3 inflammasome activation | [123] |
| Stem cell | NA | Suppressing NLRP3 inflammasome activation | [124] |
| Stem cell | NA | Regulating pyroptosis via the miR-146a-5p-TRAF6 axis | [125] |
| M2 macrophage | NA | Suppressing the ROS/NLRP3 pathway | [126] |
| Stem cell | NA | Attenuating inflammasome-related pyroptosis | [127] |
| Cancer cells | NA | Suppressing NLRP3 inflammasome activation | [128] |
| Stem cell | miR-23b | Attenuating inflammasome-related pyroptosis | [129] |
| Stem cell | miR-223-3p | Targeting NLRP3 | [130] |
| Stem cell | NA | Suppressing NLRP3 inflammasome activation | [131] |
| Stem cell | NA | Modulating miR-126 via targeting HMGB1 | [132] |
| Plasma | NA | Promoting the autophagic degradation of NLRP3 | [133] |
| Stem cell | miR-223 | Downregulating NLRP3 expression | [134] |
| Dendritic cell | NA | Downregulating NLRP3 expression | [135] |
| M2 macrophage | microRNA-148a | Inhibiting the TLR4/NF-κB/NLRP3 pathway | [136] |
| Salivary | miR-223-3p | Attenuating inflammasome-related pyroptosis | [137] |
| Neutrophils | miR-30d-5p | Upregulating NLRP3 expression through the NF-κB pathway | [138] |
| Cancer cells | TRIM59 | Inducing the ubiquitination of ABHD5 to activate the NLRP3 inflammasome activation | [139] |
| Epithelium cells | NA | Upregulating the NLRP3 inflammasome | [140] |
| Serum | NA | Activating the NLRP3 inflammasome | [141] |
| Plasma | NA | Triggering NLRP3-dependent pyroptosis | [142] |
| Plasma | NA | Triggering NLRP3 inflammasome | [143] |
| Plasma | NA | Activating the NLRP3 inflammasome | [144] |
| Serum | NA | Inhibiting the NF-κB/NLRP3 pathway | [145] |
| Plasma | miRNA-223 | Inhibiting NLRP3 | [146] |
| Renal tissues | NA | Suppressing NLRP3 activation | [147] |
NA: Not available.