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. 2024 Feb 15;15(2):154–169. doi: 10.4239/wjd.v15.i2.154

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Polyphenols have multifaceted actions to support their use in the management of type 2 diabetes mellitus. Due to their positive actions on multiple physiopathological mechanisms which are crucial not only in the onset of type 2 diabetes mellitus (T2DM) by protecting and supporting many functions of β-cells and insulin signaling, but also in those associated with common T2DM complications by improving dyslipidemia profiles, reducing systemic inflammation, dampening the deleterious consequences of the high rate formation of advanced glycation end products production, reducing oxidative stress, as well as by supporting vascular functionality. AGE: Advanced glycation end products production; GLP-1: Glucagon-like peptide-1; GLUT-4: Glucose transporter 4; BCAA: Branched-chain amino acid; DM: Diabetes mellitus.