Table 1.

Impact of neutrophils and platelets on tumor cells

Blood cell	Impact
Neutrophils	Release cytokines, chemokines, and enzymes, degrade extracellular matrix, reduce cell adhesion, and create conditions for tumor cell invasion; promote the adhesion of tumor cells to endothelial cells through physical anchoring that results to the migration of tumor cells[18,19]
Platelets	Pro-angiogenic factors from platelets enhance tumor angiogenesis to meet tumor cells’ supply needs; could form a protective film on the surface of tumor cell that allows: (1) Avoid blood flow damage as well as immune system attack; and (2) Induce the epithelial-mesenchymal transformation of tumor cells that is critical for invasiveness[19,20]