Fig. 6.

SUSP-4 improved inflammatory bowel disease (IBD) symptoms in mice after fecal microbiota transplantation (FMT). (A) Experimental process diagram. (B) Body weight change and disease activity index (DAI) score. (C) Colonic tissue measurement. (D) Hematoxylin-eosin (H&E) staining of colon. (E) Immunofluorescence staining of the colon and Western blotting. Red is zonula occludens protein 1 (ZO-1) and green is occludin. (F) Serum biochemical analysis of myeloperoxidase (MPO), malondialdehyde (MDA), total-superoxide dismutase (T-SOD), catalase (CAT), interleukin-1β (IL-Iβ), IL-6, and tumor necrosis factor-α (TNF-α). Data are presented as the mean ± standard deviation (SD) (n = 8). ^∗P < 0.05 and ^∗∗P < 0.01, compared with Model-DSS group. DSS: dextran sulfate sodium; AUC: area under the curve; DAPI: 4',6-diamidino-2-phenylindole; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.