Table 1. Potential Role of our CSF Biomarker-Associated miRNAs in AD or other Neurodegenerative Diseases Based on a Literature Search.

Specimen: Plasma
miRNAs	associated to (Aβ1–42 or P-tau181) in our analysis	potential role in AD or other neurodegenerative diseases	refs
miR-126–5p	Aβ1–42	regulates growth factor activities in neurons	(41)
miR-145-5p	Aβ1–42	targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway	(42)
miR-181a-2–3p	Aβ1–42	targets RyanR3, which mediates the release of calcium from the endoplasmic reticulum, and a dysregulation of this process has been described as linked to synaptic loss and impaired cognitive function in AD	(40)
miR-194–5p	Aβ1–42	accelerates apoptosis of Aβ1–42-transduced hippocampal neurons by inhibiting Nrn1 and decreasing PI3K/Akt signaling pathway activity	(43)
miR-3177–3p	Aβ1–42 and P-tau181
miR-323a-3p	Aβ1–42	may regulate amyloid precursor protein expression under physiological and pathological conditions	(44)
miR-342–5p	Aβ1–42	decreases ankyrin G levels	(45)
miR-22–3p	P-tau181	regulates Aβ1–42 deposit by targeting mitogen-activated protein kinase 14	(46)
miR-30e-5p	P-tau181	regulates neuroinflammation by targeting Nlrp3	(47)
miR-340–3p	P-tau181	reduces the accumulation of Aβ through targeting BACE1	(48)
miR-374b-5p	P-tau181	deregulated lncRNA MAGI2-AS3 sponges miR-374b-5p attenuates Aβ induced neurotoxicity and neuroinflammation	(49)
miR-494–3p	P-tau181	reduces DJ-1 expression and exacerbates neurodegeneration	(50)

Specimen: Serum
miRNAs	associated to (Aβ1–42 or P-tau181) in our analysis	potential role in AD or other neurodegenerative diseases	refs
miR-106–5p	Aβ1–42
miR-133a-3p/133b	Aβ1–42	regulates the maturation and function of dopaminergic neurons via suppression of paired-like homeodomain 3	(51)
miR-143–3p	Aβ1–42	inhibits aberrant tau phosphorylation and amyloidogenic processing of amyloid precursor protein in AD	(52)
miR-148b-3p	Aβ1–42
miR-20b-5p	Aβ1–42	aggravates neuronal apoptosis induced by Aβ via down-regulation of the Ras homologue family member C in AD	(53)
miR-3613–5p	Aβ1–42
miR-369–3p	Aβ1–42	loss of miR-369 promotes tau phosphorylation in AD mice	(54)
miR-4433b-5p	Aβ1–42
miR-486–3p	Aβ1–42	influences the neurotoxicity of a-Synuclein by targeting the SIRT2 gene	(55)