Table 2. Substrate Scope for the Hydrogenation of Sulfur-Containing Quinolines under Optimized Conditions^a and the Reaction Condition-Based Sensitivity Assessment.

^aReaction conditions: 1 (0.3 mmol), Ru–W–S-0.33 (6.5 mg), H₂ (40 bar), T = 80 °C, MeOH (2 mL) and reaction time = 24 h. Isolated yields are given, the diastereomeric ratio (d.r.) was determined by NMR.

^bT = 100 °C.

^cT = 120 °C.

^dT = 60 °C.