Table 2.

Multivariate logistic regression analysis of LNM in CRC.

	Odds ratio	95% CI	p value
Depth of invasion (T3-T4)	2.63	0.87-7.92	0.09
Histologic grade (G2)	4.76	1.25-18.07	0.03
Tumor size (≥3cm)	2.04	0.61-6.82	0.25
CEA (>5ng/ml)	1.19	0.50-2.84	0.70
LVI	22.38	3.97-104.68	<0.01
Perineural invasion	1.39	0.641-3.20	0.44
neoadjuvant therapy (yes)	0.12	0.01-1.63	0.11
CD38+ NK cells (high)	4.54	1.92-10.76	<0.01

LNM, lymph node metastasis; CRC, colorectal cancer; Histologic grade (G2), poorly differentiated adenocarcinomas or signet ring cell type or mucinous carcinomas; LVI, lymphovascular invasion.