Table 2.

Steps and intensity of habitual physical activity over time in the ETI group and the non-ETI group from baseline to follow-up.

	ETI group (n = 21)		non-ETI group (n = 6)		Between-group comparison p-value		Within-group comparison p-value
	Baseline	Follow-up	Baseline	Follow-up	Baseline	Follow-up	ETI group	non-ETI group
Steps (number/day)	8,798 ± 3,176 (7,352/10,243)	10,997 ± 3,468 (9,354/12,600)*	11,530 ± 3,636 (8,490/14,569)	11,164 ± 3,724 (8,716/14,908)	0 . 042	0.785	0.019	0.893
Total change (steps/day)		2,131.3 ± 3,268.7 (556.4/3,707.3)		−305.7 ± 2,628.1 (−2,351.7, 1,740.3)
Annual change in steps/day		414.0 ± 699.5 (76.9/751.2)		−86.8 ± 401.0 (457.6/284.1)	0.060
Sedentary-to-light intensity HPA (<3 METs), in min/day	1,218.5 ± 133.9 (1,149.6/1,287.4)	1,170.6 ± 117.6 (1,115.7/1,287.4)	1,254.1 ± 197.4 (763.8/1,744.4)	1,103.0 ± 136.8 (885.4/1,320.6)	0.491	0.278	0.543	0.416
Moderate-to-vigorous intensity HPA (3–5.9 METs), in min/day	106.3 ± 90.6 (60.2/140.3)	112.1 ± 74.1 (74.4/143.8)	123.0 ± 101.0 (17.0/229.0)	92.2 ± 36.8 (46.5/137.9)	0.466	0.946	0.352	0.207
Vigorous HPA (≥6 METs), in min/day	16.7 ± 18.7 (6.5/27.7)	13.6 ± 18.6 (8.2, 22.3)	19.6 ± 20.0 (2.9/36.4)	18.3 ± 18.3 (−0.9/7.6)	0.767	0.407	0.363	0.465

Values are mean ± standard deviation (95% confidence interval).

Baseline, assessment of habitual physical activity and clinical parameters; Follow-up, assessment of habitual physical activity and clinical parameters. Statistical testing: Kruskal–Wallis test (between groups); Mann–Whitney U-test (within groups); Friedman two-way analysis of variance by ranks test to compare the changes over time; Chi-Quadrat (2), χ² (post hoc tests).

HPA, habitual physical activity; ETI, elexacaftor/tezacaftor/ivacaftor; METS, metabolic equivalents.

Bold type indicates a significant result.