Table 2.
Univariable and multivariable COX regression analysis of prognostic factors associated with OS
| Variables | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR(95CI) | p-value | HR(95CI) | p-value | |
| Gender(female vs male) | 0.833(0.473–1.468) | 0.528 | - | - |
| Age (years) (< 60 vs ≥ 60) | 0.588(0.331–1.045) | 0.070 | - | - |
| Tumor size (< 4 cm vs ≥ 4 cm) | 0.930(0.528–1.639) | 0.803 | - | - |
| Differentiation status (well + moderate vs poor and undifferentiated) | 0.631(0.369–1.077) | 0.092 | - | - |
| Depth of invasion (T1 + T2 vs T3 + T4) | 0.511(0.285–0.918) | 0.025 | 0.981(0.530–1.819) | 0. 950 |
| Lymph node metastasis (N0 vs N1 + N2) | 0.195(0.100–0.379) | < 0.0001 | 0.671(0.237–1.901) | 0.452 |
| TNM stage (I + II vs III + IV) | 0.141(0.063–0.312) | < 0.0001 | 0.212(0.058–0.768) | 0.018 |
| TMEM160 (high vs low) | 2.084(1.161–3.741) | 0.014 | 1.881(1.042–3.396) | 0.036 |