Table 1.
Expression profile of ERO1α in tumors
| Cancer Type | Ref. | Data source | Positive group | Normal Control | ERO1A expression |
|---|---|---|---|---|---|
| Bile duct cancer | [62] | Cell line | Tumor cell lines (n=5) | Bile duct epithelial cell line (n=1) | ↑ (Protein-WB) |
| Tissue | Tissue microarray (n=186) | Adjacent normal tissues (n=36) | ↑ (Protein-IHC) | ||
| Cervical cancer | [63] | Tissue | Patient tumor tissues (n=15) | Adjacent normal tissues (n=15) | ↑ (Protein-WB) |
| Tissue | Tissue microarray (n=69) | Normal cervical tissues (n=9) | ↑ (Protein-IHC) | ||
| Lung cancer | [64] | Database | Patient tumor tissues (n=376, Oncomine) | Normal tissues (n=150) | ↑ (mRNA) |
| Database | Patient tumor tissues (n=483, TCGA) | Normal tissues (n=59) | ↑ (mRNA) | ||
| Database | Patient tumor tissues (n=483, TCGA + GTEx) | Normal tissues (n=347) | ↑ (mRNA) | ||
| Database | Patient tumor tissues (n=356, GEO) | Normal biopsies (n=170) | ↑ (mRNA) | ||
| [65] | Tissue | Tissue microarray (n=80) | Adjacent normal tissues (n=80) | ↑ (Protein-IHC) | |
| [66] | Tissue | Patient tumor tissues (n=102) | Adjacent normal tissues (n=102) | ↑ (Protein-IHC) | |
| Cell line | Tumor cell lines (n=4) | Lung epithelial cell line (n=1) | ↑ (Protein-WB) | ||
| [67] | Database | Patient tumor tissues (n=502, TCGA) | Normal tissues (n=49) | ↑ (mRNA) | |
| Pancreatic cancer | [68] | Database | Patient tumor tissues (n=179, TCGA + GTEx) | Normal tissues (n=171) | ↑ (mRNA) |
| Database | Patient tumor tissues (n=96, GEO) | Normal tissues (n=122) | ↑ (mRNA) | ||
| Tissue | Tissue microarray (n=205) | Adjacent normal tissues (n=205) | ↑ (Protein-IHC) | ||
| [69] | Database | Patient tumor tissues (n=145, GEO) | Normal tissues (n=46) | ↑(mRNA) | |
| Tissue | Patient tumor tissues (n=8) | Normal tissues (n=3) | ↑ (mRNA & protein, qPCR & WB) | ||
| Cell line | Tumor cell lines (n=6) | Pancreatic epithelial cell line (n=1) | ↑ (mRNA & protein, qPCR & WB) | ||
| Breast cancer | [70] | Cell line | Tumor cell lines (n=7) | Normal tissue (n=1) | ↑ (mRNA, qPCR) |
| Prostate cancer | [71] | Tissue | Patient tumor tissues (n=12) | Normal tissues (n=6) | NS (protein, WB) |
| Cell line | Tumor cell lines (n=4) | Epithelial prostate cell line (n=1) | NS (protein, WB) | ||
| Liver cancer | [58] | Tissue | Patient tumor tissues (n=114) | Adjacent normal tissues (n=114) | ↑ (mRNA & protein, qPCR & WB & IHC) |
| Database | Patient tumor tissues (n=371, TCGA) | Normal tissues (50) | ↑ (mRNA) | ||
| Cell line | Tumor cell lines (n=5) | Liver cell line (n=1) | ↑ (mRNA & protein, qPCR & WB & IHC) | ||
| Gastric cancer | [72] | Tissue | Patient tumor tissues (n=105) | Adjacent normal tissues (n=105) | ↑ (mRNA & protein, qPCR & WB & IHC) |
Duplicate data in different references was deleted and only one was retained. NS, no significance; GEO, Gene Expression Omnibus; TCGA, The Cancer Genome Atlas Program; GTEx, Genotype-Tissue Expression; WB, Western blot;IHC, Immunohistochemistry; qPCR, quantitative polymerase chain reaction.