Table 1.

MR results of causal relationships between immune cells and JIA

Outcome	Exposure	No. SNP	PIVW	PFDR	OR	95% CI	Horizontal pleiotropy			Heterogeneity
							Egger intercept	SE	P-value	Cochran’s Q	P-value
JIA	CD3 on CM CD8br	18	3.33e-05	0.024**	0.731	0.63–0.848	0.028	0.035	0.437	13.447	0.706
	HLA DR on CD14+ CD16- monocyte	22	0.000683	0.168*	0.748	0.633–0.885	0.012	0.052	0.821	40.645	0.006
	HLA DR on CD14+ monocyte	21	0.00069	0.168*	0.743	0.627–0.883	0.011	0.053	0.826	38.655	0.007

FDR, FDR, false negative discovery rate, Benjamini-Hochberg method was used for adjustment

SNP Single Nucleotide Polymorphism: OR odds ratio: CI confidence interval

*Indicates significant difference in P_FDR at 0.2 level

**indicates significant difference in P_FDR at 0.05 level