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. 2024 Mar 8;23:48. doi: 10.1186/s12943-024-01965-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Glycolysis is identified as the primary risk factor for survival. A Univariate Cox regression analysis indicated that glycolysis was the primary risk factor among various hallmarks of cancer; B Heatmap showing differentially enriched biological pathways between normal and PC tumor tissues; C Kaplan–Meier analysis showed that patients with higher ssGSEA scores of glycolysis displayed worse OS; D-E Glycolysis ssGSEA scores were significantly elevated in patients who died during follow up. Survival difference was compared using the log-rank test