Table 1.
Baseline characteristics of German Chronic Kidney Disease (GCKD) study patients stratified by cancer statusa
| Non-cancer (n = 4056)b | Prevalent cancer (n = 615)b | Incident cancer (n = 368)b | |
|---|---|---|---|
| ApoA-IV (mg/dL) | 29.0 ± 9.9 [22.0; 27.9; 34.4] | 28.1 ± 9.1 [21.6; 26.4; 33.0] | 28.7 ± 10.1 [22.0; 27.1; 33.9] |
| Age (years) | 59 ± 12 [51; 62; 69] | 65 ± 9 [60; 68; 71] | 65 ± 9 [62; 68; 71] |
| Female sex, n (%) | 1653 (40.8%) | 246 (40.0%) | 106 (28.8%) |
| eGFR (mL/min/1.73m2)c | 51 ± 20 [36; 47; 61] | 48 ± 18 [35; 46; 59] | 45 ± 17 [33; 42; 54] |
| UACR (mg/g)d | 448 ± 962 [10; 55; 422] | 365 ± 1035 [7; 30; 210] | 343 ± 782 [10; 49; 286] |
| Body mass index, (kg/m2) | 29.7 ± 6.0 [25.6;28.8;33.1] | 29.9 ± 5.7 [25.8;29.1;33.2] | 30.5 ± 5.5 [27.2;29.6;33.8] |
| Hs-CRP, (mg/L) | 4.6 ± 8.0 [1.0; 2.2; 4.9] | 5.3 ± 8.8 [1.2; 2.5; 5.7] | 5.4 ± 10.1 [1.4; 2.7; 5.7] |
| LDL cholesterol, (mg/dL) | 119 ± 44 [90; 115; 143] | 116 ± 43 [86; 112; 139] | 113 ± 41 [84; 109; 142] |
| HDL cholesterol, (mg/dL) | 52 ± 18 [40; 49; 62] | 51 ± 19 [38; 47; 61] | 50 ± 18 [38; 45; 59] |
| Triglycerides, (mg/dL) | 199 ± 129 [118; 168; 239] | 202 ± 120 [116; 169; 245] | 202 ± 133 [120; 170; 246] |
| Smoker and ex-smoker, n (%) | 2354 (58.0%) | 373 (60.7%) | 239 (65.0%) |
| Diabetes, n (%) | 1383 (34.1%) | 241 (39.2%) | 162 (44.0%) |
| Statin use, n (%) | 1918 (47.3%) | 273 (44.4%) | 204 (55.4%) |
Data are provided as mean ± SD [25th, 50th (median) and 75th percentile or number (%), (percentage considering missing values). Hs-CRP and urine-albumin values that were below the lower detection limit (LOD) were replaced by LOD/√2. BMI was corrected for amputation
aStudy participants are stratified by non-cancer patients (did not have cancer before enrolment and also not during follow-up), prevalent cancer patients (those with a history of cancer before enrolment), and incident cancer patients (those who developed a new cancer event during follow-up which has not been experienced before enrolment)
bNumber of patients based on those with available data on age, sex, eGFRcys, urine albumin-creatinine ratio (UACR), apolipoprotein A-IV measurements, cancer information and censoring date
ceGFR denotes glomerular filtration rate calculated according to the CKD-EPI equation based on cystatin C [38]
dUACR was calculated according to the following equation: albumin in urine (mg/l) × 100 / creatinine in urine (mg/dl) and is given in mg/g