Table 2.
Multivariate Cox regression analysis of the role of BMI, TyG index, TyG-BMI in assessing changes in glycemic status in patients with prediabetes
| HR (95%CI) | E-value | ||||
|---|---|---|---|---|---|
| Non-adjusted Model | Model I | Model II | Model III | ||
| Prediabetes to NFG | |||||
| TyG-BMI (per SD increase) | 0.80 (0.79, 0.82) | 0.84 (0.83, 0.86) | 0.86 (0.84, 0.88) | 0.90 (0.88, 0.93) | 1.46 |
| TyG-BMI (quartiles) | |||||
| Q1 | Ref | Ref | Ref | Ref | |
| Q2 | 0.81 (0.77, 0.85) | 0.90 (0.86, 0.95) | 0.92 (0.88, 0.97) | 0.97 (0.92, 1.02) | |
| Q3 | 0.67 (0.64, 0.71) | 0.78 (0.74, 0.82) | 0.80 (0.76, 0.85) | 0.87 (0.82, 0.93) | |
| Q4 | 0.59 (0.56, 0.62) | 0.66 (0.63, 0.70) | 0.70 (0.66, 0.74) | 0.82 (0.77, 0.89) | |
| P-trend | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | |
| Prediabetes to Diabetes | |||||
| TyG-BMI (per SD increase) | 1.43 (1.39, 1.47) | 1.40 (1.36, 1.45) | 1.38 (1.34, 1.42) | 1.26 (1.21, 1.31) | 1.83 |
| TyG-BMI (quartiles) | |||||
| Q1 | Ref | Ref | Ref | Ref | |
| Q2 | 1.56 (1.40, 1.74) | 1.41 (1.26, 1.57) | 1.38 (1.23, 1.54) | 1.27 (1.12, 1.43) | |
| Q3 | 2.17 (1.95, 2.41) | 1.90 (1.71, 2.11) | 1.83 (1.64, 2.04) | 1.57 (1.39, 1.76) | |
| Q4 | 2.81 (2.54, 3.11) | 2.52 (2.27, 2.80) | 2.39 (2.15, 2.66) | 1.82 (1.61, 2.06) | |
| P-trend | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | |
Model I adjusted for age, sex and height
Model II adjusted for age, sex, height, family history of diabetes, smoking status, drinking status, SBP, DBP
Model III adjusted for age, sex, height, family history of diabetes, smoking status, drinking status, SBP, DBP, FPG, TG ALT, BUN and Cr
Abbreviations: HR hazard ratios, CI confidence interval, other abbreviations as in Table 1