Table 3:

Effects of treatment on depressive symptoms at week 12 (primary endpoint)

	Estimate (95% CI)	p value	Cohen’s d (95% CI)
Linear mixed model for repeated measures (ITT population) *
Control vs stand-alone iCBT	6·32 (3·37–9·27)	<0·0001	0·97 (0·64–1·30)
Control vs guided iCBT	5·80 (2·71–8·88)	<0·0001	0·96 (0·62–1·30)
ANCOVA with last observation carried forward (ITT population) †
Control vs stand-alone iCBT	5·81 (3·38–8·24)	<0·0001	0·90 (0·59–1·20)
Control vs guided iCBT	5·58 (3·02–8·13)	<0·0001	0·89 (0·57–1·21)
ANCOVA with multiple imputations (ITT population) †
Control vs stand-alone iCBT	6·32 (4·20–8·45)	<0·0001	0·99 (0·67–1·31)
Control vs guided iCBT	5·71 (3·48–7·94)	<0·0001	0·94 (0·60–1·27)
ANCOVA with complete cases †
Control vs stand-alone iCBT	6·36 (3·85–8·86)	<0·0001	0·99 (0·66–1·33)
Control vs guided iCBT	5·93 (3·33–8·54)	<0·0001	0·97 (0·63–1·32)
Linear mixed model for repeated measures (mITT population) †
Control vs stand-alone iCBT	6·41 (3·37–9·46)	<0·0001	0·95 (0·61–1·30)
Control vs guided iCBT	5·97 (2·88–9·07)	<0·0001	0·94 (0·60–1·29)

Data are the difference in BDI-II score (points) between the two groups specified at week 12. BDI-II=Beck Depression Inventory-II. iCBT=internet-based cognitive behavioural therapy. ITT=intention to treat. mITT=modified intention to treat.

^*Prespecified primary analysis.

^†Prespecified sensitivity analysis.