(A) Paired bursting driven by simultaneous current injections into both cells of coupled pairs. Scale bars, 20 mV, 50 ms. (Inset) Close-up of paired burst event. (B) Mean cc and GC before and after paired bursting (gray bar). (C) Average normalized input resistance (Rin) and membrane potential (Vm) for the neurons summarized in (B). (D) Example paired responses before and after activity pairing as in (A). Scale bars, 100 ms, 2.5 mV (coupled response, in black), 5 mV (direct response, in gray). (E) Bursting driven by current injections into one cell of a coupled pair (gray trace) while the other neuron was quiescent (black trace). Scale bars, 20 mV, 50 ms. (Inset) Close-up of burst in cell 1 and burstlet in cell 2. (F) Mean cc and GC before and after single-cell bursting (gray bar). (G) Average normalized input resistance (Rin) and membrane potential (Vm) for the neurons summarized in (F). (H) Example paired responses before and after activity pairing as in (E). Scale bars, 100 ms, 2.5 mV (coupled response, in black), 5 mV (direct response, in gray).