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. 2022 Feb 16;8(7):eabl4923. doi: 10.1126/sciadv.abl4923

Fig. 5. U87 glioma suppression by Compd 27 in both a subcutaneous tumor mouse model and an orthotopic mouse brain tumor model.

Fig. 5.

(A) The schematic drawing of the in vivo experiments in these two mouse models. (B) Subcutaneous U87MG tumor growth curves after various treatments as specified. Tumor volume: means ± SD (n = 6). (C) Survival rates of mice bearing subcutaneous U87MG tumors after various treatments (n = 6). (D) Bioluminescent images of tumor progression in orthotopic U87-luciferase mice after various treatments (n = 7). Note: The mouse treated by PBS was dead before day 20. (E) Survival of mice bearing orthotopic U87MG tumors after various treatments (n = 7). (F) Representative H&E staining and Ki67 immunohistochemical staining of the intracranial tumors treated with the TMZ or TMZ + Compd 27. Statistical significance was calculated using paired two-tailed Student’s t test. *P < 0.05; ***P < 0.001.