Table 3.

Toenail Onychomycosis Cure Rates for Oral and Topical Treatment

Reference	Treatment	Mycological Cure	Clinical Cure	Complete Cure	Level of Evidence
Oral Therapy
87	Griseofulvin	29%	3%	Not established	IIB
55, 70	Itraconazole	61%	52%	47%	IB
21, 22	Terbinafine	70%	52.3%	38%	IB
102, 104	Fluconazole	79%	100%	Not established	IIB
	Voriconazole	Not established	Not established	Not established
129	Posaconazole	Not established	45.5–54.1%	Not established	IIB
137, 135, 139	Fosravuconazole L‐lysine Ethanolate	82%	11–33%	59.4%	IIB
Topical Therapy
143, 144	Amorolfine	70.6–89.3%		46–54.2%	IIB
4, 119	Ciclopirox	29%-36%	14%	5.5–8.5%	IB
126	Efinaconazole	53.4–61.6%		15.2–31.1%	IIB
139	Tavaborole	31.1–35.9%	26.1–27.5%	6.5–9.1%	IB
184	Luliconazole	Not established	Not established	14.9%	IIB

Notes: Level IA: meta-analysis of randomized controlled trials; level IB evidence: at least one randomized controlled trial; level IIA evidence: at least one controlled study without randomization; level IIB evidence: at least one other type of experimental study; level III evidence: nonexperimental descriptive studies. Level IV evidence: expert committee reports or opinions or clinical experience of respected authorities.