Table 2.
Descriptive statistics of outcomes in FAME intervention and control groups.
| Baseline | P-value | 1 Year Post Consult: | P-value | |||
|---|---|---|---|---|---|---|
| ITT Analysis | FAME Cases (N = 236) |
Control Group (N = 236) |
FAME Cases (N = 236) |
Control Group (N = 236) |
||
| Drug Burden Index (ITT) | 2.04 (1.10) | 1.65 (0.99) | 0.11 | 1.89 (1.14) | 1.55 (1.11) | 0.68 |
| Overall Mean DBI Change | −0.15 (0.57) 95% CI (−0.23,−0.08) |
−0.11 (0.79) 95% CI (−0.21, −0.00) |
0.47 | |||
| Acute Falls Events, Any | 15/236 (6.3%) | 26/236 (11%) | 0.10 | |||
| DBI Increase by ≥ 0.5 | 18 (7.6%) | 43 (18.2%) | ||||
| Odds of DBIa increase by ≥ 0.5 | OR 0.37 (0.21, 0.67) | <0.001 | ||||
| Per Protocol Analysis | FAME Cases (N = 236) |
Control Group (N = 236) |
FAME Cases (N = 147) |
Control Group (N = 236) | ||
| Drug Burden Index (DBI) | 2.04 (1.10) | 1.65 (0.99) | 0.11 | 1.82 (1.13) | 1.55 (1.11) | 0.76 |
| Overall Mean DBI Change | −0.25 (0.71) 95% CI (−0.36,−0.13) |
−0.11 (0.79) 95% CI (−0.20,−0.00) |
0.08 | |||
| Acute Falls Events, Any | 15/236 (6.3%) | 26/236 (11%) | 0.10 | |||
| DBI Increase by ≥ 0.5 | 18 (12.2%) | 43 (18.2%) | ||||
| Odds of DBIa increase by ≥ 0.5 | OR 0.63 (0.35, 1.1) | 0.12 | ||||
DBI = Drug Burden Index; FAME = Falls Assessment of Medications in the Elderly; ITT = intention to treat
a
Odds of DBI increase vs. no change or decrease by same threshold